The predictive value of serum CA-125 and NT-proBNP at different glomerular filtration rates in the prognosis of the patients with acute heart failure
Hu Taisong
Abstract：Objective To evaluate whether the baseline estimated glomerular filtration rates(eGFR)at admission affect the predictive value of carbohydrate antigen125(CA-125)and serum N-terminal pro-B-type natriuretic peptide(NT-proBNP)in the prognosis of acute heart failure(AHF)patients.Methods Prospective Cohort study was used.Patients were divided into four groups based on their baseline eGFR levels at admission:eGFR was≥60 mL/(min·1.73 m2)in Group 1,eGFR was 45-59 mL/(min·1.73 m2)in Group2,eGFR was30-44 mL/(min·1.73 m2)in Group 3,eGFR was<30 mL/(min·1.73 m2)in Group 4.The baseline data,the prognosis one year after discharge,the predictive value of baseline CA-125 and baseline NT-proBNP for the prognosis of AHF patients one year after discharge were compared and analyzed in four groups.Results ①Among 232 AHF patients,44 died from all causes within one year after discharge,with the all-cause mortality rate of 18.97%;28 cases died of cardiovascular disease within one year after discharge,with a cardiovascular mortality rate of 12.07%.② Serum CA-125(OR =1.336,P =0.000)and NT-proBNP(OR = 1.231,P =0.017)were influencing factors for all-cause mortality(CA-125:OR =1.336,P =0.000;NT-proBNP:OR = 1.193,P = 0.000)and cardiovascular death in AHF patients one year after discharge(CA-125:OR = 1.225,P = 0.000;NT-proBNP:OR = 1.193,P = 0.000).③The AUC values of serum CA-125 for predicting all-cause mortality in AHF patients one year after discharge were 0.752,0.759,0.757 and 0.764 in groups 1,2,3 and 4,respectively;The AUC values of serum CA-125 for predicting cardiovascular death in AHF patients one year after discharge were 0.779,0.748,0.774 and 0.783 in groups 1,2,3 and 4,respectively.④The AUC of the predictive value of serum NT-proBNP for all-cause mortality in AHF patients one year after discharge was 0.785,0.754,0.727 and 0.673 in groups 1,2,3 and 4,respectively;The AUC of the predictive value of serum NT-proBNP for cardiovascular death in AHF patients one year after discharge was 0.742,0.749,0.726 and 0.668 in groups 1,2,3 and 4,respectively.Conclusions In AHF patients,both CA-125 and NT-proBNP have certain prognostic predictive value,but CA-125 has higher prognostic predictive value than NT-proBNP in AHF patients with significant eGFR reduction.
Keywords：Estimated glomerular filtration rate(eGFR)N-terminal pro-B-type natriureticpeptide(NT-proBNP)Carbohydrate antigen125(CA-125)Acute heart failure(AHF)Prognosis
Publication Date：2024-03-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 206-213 )