The causal relationship between gut microbiota and bacterial pneumonia:A two-sample bidirectional mendelian randomization study and application of cML-MA
Kong Lingyi
Wang Yuanyuan
Miao Changhong
Xu Xinyi
Xiao Lu
Abstract：Objective To investigate the causal relationship between gut microbiota and susceptibility to bacterial pneumonia by using Mendelian randomization(MR)study.Methods Three different Mendian randomization analysis methods were employed in this study to analyze the relationship between 211 gut microbiota taxa and bacterial pneumonia in 211 paired samples,followed by reverse Mendian randomization analysis.The inverse variance weighting(IVW)method was used as the main outcome,with other methods serving as supplementary references.Results The study revealed that increased abundance of Mollicutes(OR=1.14,95%CI 1.02-1.27,P=0.02),Actinomycetaceae(OR=1.17,95%CI 1.02-1.35,P=0.03),Actinomycetales(OR=1.17,95%CI 1.01-1.35,P=0.03),and Tenericutes(OR=1.14,95%CI 1.02-1.27,P=0.02)was associated with increased susceptibility to bacterial pneumonia.Furthermore,increased abundance of Peptococcaceae(OR=0.88,95%CI 0.78-0.98,P=0.02),Eubacteriumrectalegroup(OR=0.85,95%CI 0.75-0.97,P=0.02),and Lachnospiraceae UCG001(OR=0.90,95%CI 0.83-0.99,P=0.03)was associated with a decreased risk of bacterial pneumonia.Sensitivity analysis and cML-MA results supported the reliability of the study findings.Reverse Mendelian randomization did not find reverse causality.Conclusions The results of this study demonstrate a correlation between increased abundance of certain gut microbial taxa and increased or decreased susceptibility to bacterial pneumonia.This gut microbiota plays an important role in the pathogenesis of bacterial pneumonia.The article provides novel insights for future researches and potential intervention strategies.
Keywords：Gut microbiotaBacterial pneumoniacML-MAMendelian randomization
Publication Date：2024-02-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 148-155 )