Causal relationship between sepsis and arrhythmia:a two-sample Mendelian randomization
Yang Mengxia
Zhao Chunming
Chen Tengfei
Xu Xiaolong
Liu Qingquan
Abstract：Objective To explore the causal relationship between sepsis and arrhythmia.Methods Using the published genome-wide association analysis as the data source,single nucleotide polymorphisms significantly associated with sepsis were screened as instrumental variables.The method of two-sample Mendelian randomization,which included inverse variance weighted method,weighted median method,MR Egger analysis method,simple model method and weighted model method,were used to evaluate the causal relationship between sepsis and arrhythmia.At the same time,heterogeneity analysis,pleiotropy analysis and sensitivity analysis were used to evaluate the reliability and stability of the results.Results 52 strong instrumental variables were screened out for the analysis of two-sample Mendelian randomization,only the inverse variance weighting analysis showed statistical difference(OR=1.002,95%CI 1.001-1.003,P=0.002),and the results of the other four analysis methods had no statistical difference(P>0.05),but the effect value β was in the same direction as that of inverse variance weighting method;The results of heterogeneity analysis,pleiotropy analysis,and sensitivity analysis all showed P>0.05.Conclusions There is a causal relationship between sepsis and arrhythmia,and sepsis increases the risk of arrhythmias.
Keywords：SepsisArrhythmiaMendelian randomizationCausal relationshipSingle nucleotide polymorphismsInverse variance weighting
Publication Date：2024-02-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 142-147 )