Effect of targeted temperature management on neurological outcome and survival rate in the patients with extracorporeal cardiopulmonary resuscitation
Wang Haizhen
Cheng Pengfei
Guo Luyao
Wang Meiling
Xu He
Gu Peipei
Wu Jinjing
Yang Minfei
Abstract：Objective To evaluate the effect of targeted temperature management(TTM)on neurological outcome and survival rate in the patients with extracorporeal cardiopulmonary resuscitation(ECPR).Methods We searched the literatures of PubMed,Cochrane Library,Elsevier,Web of Science,Ovid,CNKI,Wanfang,SinoMed,and China Medical Journal Full-text Database about the effect of TTM on the outcomes of patients with ECPR.The search time limit was from the establishment of the database to June 1,2023.In strict accordance with the inclusion and exclusion criteria,the data were extracted,and the quality of the literatures was evaluated.RevMan 5.3 software was used for Meta analysis of the included studies.Results A total of 8 studies involving 3 687 patients were included.Compared with the non-TTM group,TTM did not significantly improve the survival rate at discharge(OR=0.98,95%CI 0.82-1.15,P=0.77)and neurological outcome(OR=1.37,95%CI 0.89-2.13,P=0.16).There was no significant difference in the incidence of extracorporeal membrane oxygenation(ECMO)-related complications including bleeding,lower limb ischemia,renal injury and infection between the two groups(OR=1.24,95%CI 0.91-1.68,P=0.17).Conclusions TTM does not significantly improve the neurological outcome and survival rate of patients with ECPR,but does not aggravate the incidence of ECMO-related complications.
Keywords：Extracorporeal cardiopulmonary resuscitation(ECPR)Heart arrestTargeted temperature managementSurvival rateNeurological functionExtracorporeal membrane oxygenation(ECMO)Meta analysis
Publication Date：2024-02-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 133-141 )