Diagnosis and treatment pathway for hereditary angioedema in the emergency department
Zhou Ning
Han Xiaotong
Chen Song
Sun Peng
Liu Bin
Du Junkai
Zhang Chunyang
Guo Geng
Dou Qingli
Jiang Wei
Lv Chuanzhu
Zhu Huadong
Zhang Mao
Abstract：Hereditary angioedema(HAE)is an autosomal dominant disease characterized by recurrent skin and mucosal edema.Edema can occur anywhere,but laryngeal edema is the most deadly and can lead to asphyxia and be life-threatening.It can be easily misdiagnosed as acute abdominal disease if edema affects the mucous membranes of the gastrointestinal tract,with the symptoms of abdominal pain and vomiting.Edema of the face,trunk,and extremities also significantly affects patients'quality of life.In order to improve the recognition of emergency department physicians,the panel of expert formulated the diagnosis and treatment path.In addition to introducing the pathogenesis and clinical manifestations of HAE,the pathway also summarizes HAE cases from emergency department which were previously published in Chinese journal,so that physicians could understand the disease better.The pathway also provides a flowchart of HAE diagnosis in the emergency department as a reference for clinical practice.
Keywords：Hereditary angioedemaAngioedemaEmergency departmentDiagnosisComplement C4C1-inhibitorFresh-frozen plasmaIcatibant injection
Publication Date：2024-02-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 99-105 )