Predictive value of serum PCT, CRP and IL-6 on lung infection in elderly patients with severe brain injury
Xiao Hua
Zhuo Fen
Huang Juan -juan
Cai Yue - hong
Abstract：Objective To investigate the predictive value of serum procalcitonin ( PCT), C-reactive protein (CRP) and interleukin-6 ( IL-6) on lung infection in elderly patients with severe brain injury. Methods One hundred and seventy-two cases of elderly severe brain trauma treated in our hospital from January 2015 to December 2017. They were divided into infection group (81 cases) and non-infection group (91 cases) according to whether they had pulmonary infection. The changes of serum PCT, CRP and IL -6 levels in two groups on the first, third, fifth day after admission were compared. The predictive value of serum PCT, CRP and IL-6 levels in each time point for pulmonary infection was analyzed by ROC curve. Results The levels of serum PCT, CRP and IL -6 in the infected group were significantly higher than those in the non-infected group on third day and fifth day [PCT (ng/mL): 0. 97 ± 0. 65 vs. 0. 62 ± 0. 28, 2. 41 ± 1. 26 vs. 0. 48 ± 0. 17; CRP (mg/L): 88. 63 ± 15. 41 vs. 74. 50 ± 12. 28, 92. 48 ± 18. 74 vs. 62. 38 ± 9. 51; IL -6 (ng/L): 85. 62 ± 22. 37 vs. 64. 38 ± 16. 50, 94. 26 ± 28. 50 vs. 57. 30 ± 12. 48, all P<0. 05]. The levels of serum PCT, CRP and IL-6 on the third day and fifth day of infection group were significantly higher than those on the first day [PCT (ng/mL): 0. 97 ± 0. 65 and 2. 41 ± 1. 26 vs. 0. 60 ± 0. 31; CRP (mg/L): 88. 63 ± 15. 41 and 92. 48 ± 18. 74 vs. 67. 24 ± 10. 25; IL-6 (ng/L): 85. 62 ± 22. 37 and 94. 26 ± 28. 50 vs. 54. 83 ± 12. 16, all P<0. 05]. The ROC curve showed that PCT, CRP and IL-6 on the third day combined prediction of pulmonary infection in elderly patients with severe brain injury of AUC (95% CI) with 0. 904(0. 845 -0. 966 ) was significantly higher than PCT d3 [ 0. 826 ( 0. 768 -0. 887 ), CRP d3 [0. 805(0. 748-0. 865) and IL-6 d3 [0. 773 (0. 715 -0. 835), the sensitivity and the specificity were 90. 6% and 85. 2% . Conclusion It is of great value to combined the third day PCT, CRP and IL-6 to predict lung infection in elderly patients with severe brain injury.
Keywords：Severe brain traumaProcalcitonin (PCT)C- reactive protein ( CRP)Interleukin-6 (IL-6)Lung infectionPredictive value
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 20-24 )