The changes of renal perfusion evaluated by contrast-enhanced ultrasonography on state of intra-abdominal hypertension
Sui Feng
Zheng Yue
Ma Wen-liang
Huang Li-feng
Li Wen-xiong
Cao Wen
Abstract：Objective Intranet-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are common complications in trauma and surgical intensive care unit.The increasing abdominal pressure can cause the decrease of blood perfusion of kidney and renal injury.To evaluate the change of renal blood perfusion by the examination of contrast-enhanced ultrasonography (CEUS) in intra-abdominal hypertension porcian model.Methods In 12 pigs,IAP was increased stepwise to 10,15,20,25 mm Hg while hemodynamic parameters,urinary output,renal contrast enhanced ultrasound (CEUS) and LDPI pictures were all recorded.Results With IAP elevated to 25 mm Hg gradually,compared to the baseline,the piglets showed markedly longer wash in time (WIT) and time to peak (TTP) (P ＜0.05),but significantly declines of peak intensity (PI),wash in slope (WIS) and area under curve (AUC) (P ＜ 0.05) in CEUS.With the increasing of abdominal pressure the perfusion unit was significantly decreased.PI showed a moderate correlation with PU (r =0.83,P ＜ 0.05) and AUC showed negative correlation with PU.Conclusion CEUS is a safe,real-time dynamic,noninvasive and simple technique to evaluate renal microvascular perfusion in IAH state.PI and AUC could be used for the diagnosis of the renal microvascular damage in a porcine model of IAP-induced renal impairment.LDPI is a very useful tool to evaluate the change of microcirculation.
Keywords：Intra-abdominal hypertension(IAH)Abdominal perfusion pressure(APP)Acute kidney injury(AKI)Contrast enhanced ultrasonography(CEUS)Laser Doppler perfusion imaging(LDPI)Abdominal compartment syndrome (ACS)
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 425-430,封3 )