The effect of norepinephrine combined with sodium phosphocreatine on the early cardiac function of patients with septic shock
Kang Da-wei
Yu Jian
Ju Ming-fei
Abstract：Objective To investigate the effects of norepinephrine (NS) combined with sodium phosphocreatine(SP) on the early heart function of patients with septic shock.Methods A prospective cohort study was conducted in 40 patients suffering from septic shock with the duration ＜ 24 hours admitted to the Emergency Department of Chengde Medical College Affiliated Hospital during May 2016 to May 2017.The patients were randomly divided into NS group (n =20) and NS + SP group (n =20).The patients were observed ejection fraction (EF％),brain natriuretic peptide (BNP),cardiac troponin T (cTnT),lactate (Lac),and Marshall heart score (PAR value) 0,24,72 h of admission;correlation of BNP,cTnT and EF％ was analyzed;28-day survival analysis was also done.Results ①Compared with the 0 h,at 24 h EF％ increased significantly (P ＜ 0.01),BNP,cTnT,Lac,PAR decreased significantly (P ＜0.01).Compared with NS group,EF％,Lac and PAR had no obvious abnormalities (P ＞ 0.05),BNP,cTnT decreased significantly in NS + SP group(P ＜ 0.01).②Compared with the NS group at 72 h,the EF％ increased significantly (P ＜ 0.01),BNP,cTnT,Lac and PAR decreased significantly (P ＜0.01).③BNP and cTnT were significantly negatively correlated with EF％ (P ＜0.01).④ Compared with the 28-day survival rate in NS group,the increase of NS + SP group was significant (P ＜ 0.05).Conclusion SP can be used to improve the cardiac function of sepsis at the early stage with NS.This mechanism may reduce the expression of BNP and cTnT.
Keywords：Norepinephrine(NS)Sodium phosphocreatine(SP)Marshall heart scoreBrain natriuretic peptide (BNP)Cardiac troponin T (cTnT)
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 319-322 )