Multivariate analysis on the association between early enteral nutrition and ventilator-associated pneumonia

Zhu Yu; Xu Wen-xiu; Ouyang Li-ping; Xue Li-mei; Zhang Qian

doi:10.3969/j.issn.1002-1949.2018.03.008

Abstract：Objective To observe on the association between early enteral nutrition and ventilator-associated pneumonia(VAP). Methods The study cohort was all artificial airway patients who admitted in ICU from January 2012 to March 2016 in our hospital, with the help of the hospital infection real time monitoring system,we recorded the incidence of ventilator associated pneumonia in all patients with mechanical ventilation. At the same time, we monitored the patients who have early enteral nutrition. Nested case-control study and Logistic regression were used to compare the relationship between VAP and early enteral nutrition. Results According to the ratio of 1: 3,the total of 32 VAP patients and 105 non-VAP patients were enrolled in the study. In the study group, only 11 cases had early enteral nutrition,while 68 in the control group had early enteral nutrition. No statistically significant differences were found between the two groups at age and gender. There was no significant difference between the two groups in the diagnosis of admission and underlying diseases. Between the two groups of patients, admission days(38.09 ±23.43; 26.13 ±12.97), ICU stay (26.38 ± 20.65; 15.75 ±7.667), mechanical ventilation days (22.41 ±19.93; 11.22±5.64) difference was statistically significant (P ＜0.05 ). The OR value of early enteral nutrition and VAP was 0.285. Early enteral nutrition was negatively correlated with VAP. Conclusion Early enteral nutrition in patients with ICU mechanical ventilation can effectively reduce the risk of developing VAP,early enteral nutrition can shorten the number of days of antibiotic use, reduce the duration of mechanical ventilation and hospital stay.