Protective effect of CRRT combined with ECMO against acute respiratory distress syndrome ( ARDS) in canines
He Yu-qin
Mei Xue
Shang Ming-xu
Zhang Jing-jing
Zhan Qing-yuan
Abstract：Objective To investigate the mitigation of continuous renal replacement therapy ( CRRT ) to extracorporeal membrane oxygenation related systemic inflammatory response syndrome ( ECMO-related SIRS) and the lung protection against acute respiratory distress syndrome ( ARDS) in canines.Methods Thirty adult canines were randomly divided into four groups: control group; sham group, ECMO (EC) group, ECMO+CRRT (EC+CR) group.Nine points of blood specimen of IL -6 and TNF –α during treatment and homogenate of lungs after treatment were examined .Pathology specimen of canine lung according to gravity dependent or non -gravity dependent space was attained;the lungs tissue wet/dry ratio was assessed.Results Serum inflammatory cytokines (IL-6, TNF-α) significantly increased after the start of treatment .Compared with EC group , the concentration of IL -6 and TNF-αin EC+CR group decreased after 2～4 hours and 1～2 hours respectively (P<0.05). The pathology score and wet/dry ratio indicated that EC +CR was better than EC group , the lung tissue homogenates revealed that there was a significance between EC group and EC +CR group about inflammatory cytokines (P<0.05).Conclusion In the ECMO-related SIRS-aggravated lung injury model, there is a certain mitigate effect on ECMO -related SIRS by CRRT, and there might be an alleviated effect to lung injury .
Keywords：Continuous renal replacement therapy ( CRRT )Extracorporeal membrane oxygenation (ECMO)Acute respiratory distress syndrome (ARDS)
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 84-88 )