The diagnostic value of procalcitonin (PCT) in patients with sepsis -associated acute kidney injury
Wang Xue-ting
Gao Xue-hua
Guan Yin
Luo Yan-nian
Lian Fo-yan
He Nan-nan
Li Pei-jie
Cao Wen
Abstract：Objective To evaluate the early diagnostic value of procalcitonin (PCT) in patients with sepsis-associated acute kidney injury (SA-AKI).Methods We collected the clinical data in the Second Hospital of Lanzhou University Critical Care Medicine Ⅱ in 2016 .This retrospective study included 97 patients with sepsis , according to the presence of renal injuries , they were divided into Non-AKI and AKI groups, AKI 42 cases, N-AKI 55 cases.We compared the patients′gender, age, PCT, Cys-C, IL -6, acute physiology and chronic health evaluation Ⅱ( APACHEⅡ), sequential organ failure assessment ( SOFA) between the two groups .Logistic regression was used to analyze the correlation between PCT , Cys-C, IL-6, APACHEⅡ, SOFA and SA-AKI.The receiver-operating characteristic( ROC) was drawn to compare the predictive value of the early diagnosis of SA -AKI by PCT, Cys-C and IL-6.Results ①The single factor analysis of two groups of patients with gender and age had no statistical differences (P>0.05), PCT, Cys -C, IL-6, APACHEⅡ score, SOFA score showed statistical differences (P<0.05);②The results of Logistic regression analysis of variables with statistical differences in single factor analysis showed:SOFA score (OR=2.395, 95％CI 1.417-4.050, P=0.001), PCT (OR=1.592, 95％CI 1.132-3.244, P=0.018), Cys-C(OR=1.425, 95％CI 1.120 -3.237, P=0.015), IL-6(OR=1.211, 95％ CI 0.999-2.003, P=0.037), SOFA scores, PCT, Cys -C and IL-6 were independent risk factors for SA -AKI.③The area under the ROC curve for PCT was 0.796, the value of diagnose SA -AKI was higher than Cys -C and IL-6.When PCT >13.685 ng/mL, the sensitivity of diagnose SA -AKI was 59.3％ and the specificity was 92.7％.Conclusion PCT is an independent risk factor for SA -AKI, has high diagnostic value for SA -AKI in the early.
Keywords：Procalcitonin (PCT)Interleukin -6 (IL-6)Cystatin C (Cys -C)Acute physiology and chronic health evaluationⅡ( APACHEⅡ)Sequential organ failure assessment ( SOFA)Sepsis associated acute kidney injury ( SA-AKI)
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 80-83 )