Multivariate analysis of prognosis of sepsis patients in ICU
Liang Jian-feng
Li Zhi-yong
Dong Hai-shan
Zhang Wei
Xu Chang
Gao Mao-long
Abstract：Objective To explore the prognostic factors of intensive care unit (ICU) sepsis patients, to guide clinicians to take effective control measures .Methods The clinical data of ICU 759 patients with sepsis from January 2006 to December 2016 were analyzed retrospectively .Among them, 278 patients died and 481 patients survived .Survivors and death groups were treated as dependent variable, gender, age, reason of ICU admission, acute physiology and chronic health evaluation Ⅱ(APACHEⅡ) score, the mechanical ventilation, mechanical ventilation reason, length of mechanical ventilation, successful weaning, nosocomial infection, acute kidney injury (AKI), continuous blood purification (CBP), septic shock, hemodynamic monitoring, blood transfusion, length of ICU stay, was used as the independent variable .First, the measurement data and counting data were analyzed by single factor analysis.Second, the independent variables influencing the dependent variable were obtained by univariate analysis .Third, the independent variables were analyzed by Logistic regression analysis . Results The univariate analysis showed that the independent variables were : mechanical ventilation , successful weaning , nosocomial infection , AKI, CBP, septic shock, hemodynamic monitoring , blood transfusion, reason of ICU admission, mechanical ventilation reason , APACHEⅡ score, length of ICU stay.Logistic regression analysis of the relevant factors showed that the four independent variables of APACHEⅡscore, successful weaning , AKI and septic shock had an effect on the dependent variable of death or survival.Regression coefficient of APACHEⅡscore is -0.044, the Wald value is 4.550, P=0.033, Exp (B) is 0.957.Regression coefficient of successful weaning is -4.139, the Wald value is 150.067, P=0.000, Exp (B) is 0.016.Regression coefficient of AKI is 1.269, the Wald value is 11.981, P=0.001, Exp(B)is 3.559.Regression coefficient of septic shock is 1.176, the Wald value is 9.936, P=0.002, Exp(B) is 3.240.Conclusion More factors affect the prognosis of ICU sepsis patients.APACHEⅡscore, whether the success of weaning , whether the occurrence of AKI , whether the occurrence of septic shock , are independent prognostic factors for the prognosis of ICU sepsis patients .
Keywords：Intensive care unit(ICU)Septic shockSepsisPrognosisInfluencing factors
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 46-52 )