Diagnosis and evaluation of Galectin-3 in patients with heart failure

Zhang Bo; Zhang Yan-hong; Deng Yang

doi:10.3969/j.issn.1002-1949.2018.01.009

Abstract：Objective To investigate the diagnosis and evaluation of Galectin -3 in patients with heart failure .Methods Forty patients with heart failure were included in this study .Before and after treatment, Galectin -3, BNP were measured.The relationship between Ga -3 and BNP was analyzed .One week after treatment , echocardiography was performed and EF , LVEDD were measured . The relationship between Ga -3, BNP and EF, LVEDD was analyzed.The treatment effect was divided into effective group and ineffective group .The levels of Ga-3, BNP of the two groups were compared . Grouping according to cardiac function , correlation between Ga -3 and cardiac function classification was analyzed .The patients were followed up for 3 months to record the information about rehospitalization and death .Results ①Correlation analysis showed that the serum levels of Ga -3 and BNP, LVEDD, cardiac functional grading had a positive correlation;Correlation analysis showed that the serum levels of Ga-3, BNP and EF had a negative correlation .②The effective rate of BNP in treatment group was significantly lower than that before treatment ( P<0.05);No significant decrease was seen in Ga -3 ( P>0.05).After treatment, the Ga -3 and BNP of the treated group were significantly higher than those before treatment (P<0.05).③The patients were followed up for 3 months, the level of Ga-3, BNP in the adverse event group was significantly higher than that in the group without adverse cardiac events . Conclusion In patients with heart failure , correlation analysis shows that the serum levels of Ga-3 and cardiac hypofunction , myocardial remodeling have a negative correlation .It can assess the prognosis in patients with heart failure .It can be used as a new biomarker for diagnosis , treatment, risk stratification and evaluation of prognosis in patients with heart failure .