The study of changes of serum HIS 5-HT and cytokine in patients with jellyfish sting
Huo Shu-hua
Tian Ying-ping
Xu Shu-guang
Su Xiao-yun
Liu Ji-qiang
Abstract：Objective To study the changes and clinical significance of the levels of serum histamine (HIS),5-hydroxy tryptamine (5-HT),tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients with jellyfish sting.Methods Eighty patients receiving treatment in the Beidaihe Hospital from July 2015 to August 2016 were divided into mild,moderate and severe sting group,and 28 healthy workers in the hospital were taken as normal control group.The levels of serum HIS,5-HT,TNF-α and IL-6 were measured by ELISA,and the difference were analyzed.Results The levels of serum HIS,5-HT,TNF-α and IL-6 in the experimental group were significantly higher than those in the control group,with statistical significance (P ＜ 0.01).The levels of serum HIS,5-HT,TNF-α and IL-6 in the moderate and severe group were significantly higher than those in the mild group,with statistical significance (P ＜0.01).The levels of serum HIS,5-HT,TNF-α and IL-6 in the severe group were significantly higher than those in the moderate group,with statistical significance (P ＜ 0.01),but there were no significant differences between the mild group and the control group (P ＞ 0.05).Conclusion These results suggest that the higher the levels of serum HIS,5-HT and cytokine,the severer degree of jellyfish sting.Early application of anti-inflammatory,anti-histamines may have important implication for improving the prognosis of patients with jellyfish sting.
Keywords：Jellyfish stingHistamine (HIS)5-hydroxy tryptamine (5-HT)CytokinePrognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1143-1147 )