Efficacy and mechanism of action of ulinastatin for treatment of systemic inflammatory response syndrome associated with acute severe cerebral hemorrhage
Li Jian-guo
Guo Wei
Shan Kai
Xu Bin
Yang Tie-cheng
Dong Xiao-yan
Chen Bi-yao
Du Han-yang
Hao Feng
Mu Hong
Abstract：Objective To evaluate the clinical efficacy,safety and mechanism of action of ulinastatin for the treatment of systemic inflammatory response syndrome (SIRS) associated with acute severe cerebral hemorrhage.Methods The patients with acute severe cerebral hemorrhage-associated SIRS were randomized into the treatment group and control group to receive standard of care.Ulinastatin was administered as add-on in the treatment group and the same volume of physiological saline was administered as control in the control group.Serum TNF-α,IL-1 and IL-6 levels were measured before and after treatment.Results One hundred patients with acute severe cerebral hemorrhage-associated SIRS were randomized into the treatment group (n =50) and control group (n =50).No significant differences in population data were seen between both groups.At Day 1 and Day 7,the ulinastatin treatment group had statistically significantly lower serum levels than the control group [(9.65 ± 3.72) pg/mL,(6.82 ± 4.64) pg/mL],IL-1 [(5.33 ± 2.36) pg/mL,(3.62 ± 2.56) pg/mL] and IL-6[(11.65 ± 5.67) pg/mL,(8.52 ± 4.85) pg/mL] (P ＜ 0.05).At Day 7 and Day 28,the treatment group had a statistically significantly lower NIHSS score and incidence of multiple organ dysfunction syndrome (MODS) than the control group [(14.5 ± 5.2) scores,(12.1 ± 5.4) scores,(40.8％,66.6％)],(P ＜ 0.05).Conclusion Ulinastatin effectively reduces the serum TNF-α,IL-1 and IL-6 levels in patients with acute severe cerebral hemorrhage-associated SIRS,thus reducing the incidence of MODS and improving prognosis.
Keywords：Cerebral hemorrhageSystemic inflammatory response syndrome SIRS)Tumor necrosis factor-α (TNF-α)InterleukinUlinastatin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1139-1142 )