Clinical efficacy of Xuebijing injection in septic patients with thrombocytopenia

Yu Mei-xia; Wang Bing; Wang Yong-qiang; Gao Hong-mei

doi:10.3969/j.issn.1002-1949.2017.12.004

Abstract：Objective To observe the effect of Xuebijing on inflammatory reaction,endothelium dysfunction and platelet activation in septic patients with thrombocytopenina(TCP).Methods A total of 61 septic pactients with TCP in Intensive Care Unit of Tianjin First Central Hospital from January 2015 to January 2016 were included in this prospective study.The people who came at the same period for physical examination were taken as the normal control group (n =15).Randomly divided the 61 patients into non-Xuebijing group A (n =30) and Xuebijing group B (n =31),according to the principle of minimum distribution imbalance index with age,scores of acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ),platelet count three factors.Both group A and group B received conventional therapy,group B add Xuebijing injection for 7 days.The level of serum von Willebrand factor (vWF),TNF-α and plasma sCD40L were measured by enzyme linked immune sorbent assay (ELISA).The 28-day mortality of the two groups was traced.Results ①Compared with pre-treatment,the platelet count of group A,B improved significantly post-treatment (P ＜0.05 & P ＜0.01),on the first and third day of admission,there was no significant difference between group A and group B (P ＞ 0.05),on the fifth and seventh day of admission,the platelet count of group B was higher than group A (P ＜0.05).②Compared with pre-treatment,the level of vWF,TNF-α and sCD40L of group B decreased significantly post-treatment (P ＜ 0.01 & P ＜ 0.05),and the level of vWF,sCD40L of group A increased significantly post-treatment (P ＜ 0.05).However,TNF-α had no significant change before and after treatment (P ＞ 0.05).The level of vWF,TNF-α and sCD40L of group B was lower than group A after treatment (P ＜ 0.05).③The 28-day mortality of group A and B had no significant difference (P ＞ 0.05).Conclusion Xuebijing injection reduces the sepsis inflammatory reaction,protects endothelial function,downregulates platelet activation,and improves the situation of low platelet count of septic patient with TCP.