The value of serum citrulline in predicting the early acute gastrointestinal injury after severe trauma
Wang Rui
Li Pei-jie
Yin Lu-lu
Su Cheng-yang
Zhang Zhi-cang
Abstract：Objective To investigate the serum clinical significance of semmcitrulline level in predicting the early acute gastrointestinal injury and organ failure by measuring the level of citrulline at different time points in patients with severe trauma.Methods The 72 patients after severe trauma in MICU of the Second Hospital of Lanzhou University were studied prospectively from August 2015 to December 2016.The patients were divided into mild trauma group (ISS ＜ 16) and severe trauma group (ISS ≥ 16) according to trauma severity score ISS,and divided into four groups,AGI 0 group,AGI 1 group,AGI 2 group,AGI 3 group according to the 2012 European Critical Care Medicine Association (ESICM) AGI classification guidelines.We selected the people for health examination as a normal control group.The basic chnical data and the grade of AGI were collected.The levels of serumcitrulline were measured by high performance liquid chromatography on day 1 and day 3.Results Compared to the normal control group,the serum citrulline levels in the minor trauma group and the severe trauma group were both reduced obviously after trauma(P ＜0.01 or P ＜0.05),with lower level in the severe traumatic group than that in the minor trauma group(P ＜ 0.01).The serum citrulline levels in both group decreased gradually at day 3 (P ＜ 0.01).The higher grade of AGI,the lower the level of serum citrulline (P ＜ 0.01 or P ＜ 0.05),each group of citrulline levels were further reduced at day 3 (P ＜ 0.01).The level of serum citrulline was negatively correlated with AGI severity,SOFA score and APACHE Ⅱ score.Citrulline≤19.07 μmol/L is the best value of predicting AGI after severe trauma.Conlusoin The decreased serum citrulline in patients with severe trauma is closely related to the severity of trauma and has a certain clinical value in predicting early AGI and MODS.
Keywords：Severe traumaAcute gastrointestinal injury (AGI)Serum citrulline
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1020-1024 )