Dynamic arterial elastance predicts arterial pressure response when decreasing the norepinephrine dosage in shock after coronary artery bypass graft
Liang Feng-ming
Wang Qiu-hui
Xu Hong-yang
Yang Ting
Dong Liang
Jin Ke
Yan Zheng
Yan Jie
Abstract：Objective To evaluate dynamic arterial elastance (Eadyn) as a predictor of arterial pressure response when decreasing the norepinephrine (NE) dosage in shock after coronary artery bypass graft (CABG).Methods A prospective observation of 82 patients suffering from shock after coronary artery bypass graft (CABG) for whom the physician planned to decrease the NE dosage was preformed.Measurements of hemodynamic and PiCCO variables were recorded before and after decreasing the NE dosage.Arterial pressure responsiveness was defined as a ≥ 15％ decrease in mean arterial pressure (MAP).The correlation between Eadyn and arterial pressure responsiveness when decreasing the NE dosage was analyzed with receiver operating characteristic (ROC) curve.Results 82 patients with shock after CABG were conducted,with 36 in responsive group and 46 in unresponsive group.Eadyn was lower in responders than in nonresponders (P ＜ 0.05).Eaayn ≤ 0.96 was found to predict arterial pressure responsiveness with a sensitivity and specificity of 94.4％ and 87.0％,respectively.Conclusion In patients with shock after CABG treated with NE,Eadyn may predict the decrease in arterial pressure when decreasing NE dose.
Keywords：Coronary artery bypass graft (CABG)ShockNorepinephrine (NE)ArteryElastance
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1015-1019 )