Triglyceride to high -density lipoprotein cholesterol ratio predicts worse outcomes after acute ischemic stroke
Sun Cai-zhi
Deng Qi- wen
Zhang Zheng
He Xiao- wei
Abstract：Objective The effect of triglyceride(TG)to high -density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C)on clinical outcomes of acute ischemic stroke(AIS)patients is unclear. This study sought to determine whether the TG/HDL - C in AIS patients is associated with worse outcomes. Methods AIS patients were enrolled in this study. TG, total cholesterol( TC) , HDL-C, and low-density lipoprotein cholesterol ( LDL - C ) were collected on admission. We defined 2 endpoints according to the modified Rankin scale(mRS)score at 3 months after symptom onset(excellent outcome, mRS 0~1 and death, mRS 6). Results Higher TG, non-HDL-C and TG/HDL-C were strongly associated with the 2 endpoints after adjustments: excellent [ odds ratio ( OR) =1. 39, OR =1. 89 and OR=2. 34, respectively)and death(OR=0. 59, OR=0. 29 and OR=0. 26)]. According to the receiver operator characteristic ( ROC ) analysis, the best discriminating factor was a TG/HDL - C≥0. 87 for excellent outcomes[area under the ROC curve(AUC)0.596, sensitivity 73.3%, specificity 42.7%]and non-death(AUC 0. 674, sensitivity 67. 8%, specificity 60. 6%). Patients with a TG/HDL-C<0. 87 had a 2. 94-fold increased risk of death compared with patients with a TG/HDL-C≥0. 87. Conclusion A lower TG/HDL-C is independently associated with death and worse outcome at 3 months in AIS.
Keywords：Acute ischemic stroke(AIS)Triglycerides(TG)High-density lipoprotein cholesterol( HDL-C)Modified Rankin scale( mRS)Outcome
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 923-928 )