Research advances on the protection of therapeutic hypothermia against ST-segment elevation myocardial infarction
Wang Yong-sheng
Wang Lian-sheng
Abstract：Early and successful restoration of myocardial perfusion is the most effective strategy to reduce infarct size and improve clinical outcomes in patients with acute myocardial infarction (AMI).But, reperfusion itself causes myocardial damage by ischemia/reperfusion injury as well.Data of experiments have shown that therapeutic hypothermia (TH) 32~34 ℃ could attenuate the reperfusion injury, prevent no-flow and improve ventricular remodeling in AMI models.However, inconsistent with those animal experiments, most clinical trials did not attain the same beneficial effects from TH in patients with AMI.Most recent meta-analysis reported that the benefit of TH still be observed in large infarct patients cooled rapidly before reperfusion.Novel strategies, including local induction of myocardium hypothermia and pre-hospital cooling, might be more beneficial in future.
Keywords：Therapeutic hypothermia(TH)Acute myocardial infarction(AMI)Ischemia/reperfusion injuryCardioprotection
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 855-859 )