Role of angiotensin-converting enzyme in shock-induced multiple organ injury
Su Kun
Xue Jun
Zhao Zi-gang
Niu Chun-yu
Abstract：Angiotensin-converting enzyme (ACE) is an important component of renin-angiotensin system, and is associated with pathogenesis of multiple diseases.Various shocks induce excessive and uncontrolled inflammatory response, abnormal hemodynamics, intestine barrier injury and vascular hyper-permeability, which are important factors of multiple organ injury and death.The expressions of ACE, angiotensin Ⅱ (AngⅡ), and Ang Ⅱ type 1 receptor (AT1R) are increased in different organs during the various severe pathological process of endotoxic shock, hemorrhagic shock, ischemia-reperfusion injury, and burn shock.Inhibition of ACE-Ang Ⅱ-AT1R expressions plays a positive role in alleviating organ injury.The present article reviews the role of ACE in shock-induced multiple organ injury, therefore, provides a novel approach for treatment of shock through ACE.
Keywords：Angiotensin-converting enzyme (ACE)ShockMultiple organ injury
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 839-845 )