The effect of nicorandil on myocardial perfusion in patients with NSTEMI after elective PCI
Wei Li-ye
Xia Yue
Qi Guo-qing
Yang Zhi-yu
Zhao Hong-liang
Abstract：Objective To assess the effect of nicorandil on myocardial perfusion in patients with NSTEMI after elective PCI.Methods 60 patients with NSTEMI were randomly assigned to two groups: control group (CON) and nicorandil group (NIC).The coronary angiography and PCI were performed after 10 days.The corrected TIMI frame count (CTFC) and myocardial blush grade (MBG) were calculated.Patients were followed up for 6 months.Major adverse cardiac events (MACEs) were also measured.Results There were no significant differences in baseline characteristics between the two groups (P>0.05).The CTFC parameter in NIC group was significantly lower than that in CON group [(18.4 ±3.6) vs.(25.3±2.2), P<0.01].The ratio of final MBG grade-3 was significantly higher (P<0.05) in NIC group (86.7%) relative to CON group (60.0%).Patients were followed up for 6 months and the occurrence of MACEs in NIC group was significantly lower than that in CON group (10.0% vs.26.7%, P<0.05).Conclusion Nicorandil can improve the situation of myocardial reperfusion after elective PCI in patients with NSTEMI.
Keywords：Acute myocardial infarction (AMI)Percutaneous coronary intervention (PCI)Coronary microvascularNicorandil
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 800-802 )