The discrimination and calibration of uric acid for prognosis prediction of traumatic brain injury
Chen Du
Bao Long
Xu Feng
Lu Shi-qi
Abstract：Objective To investigate the value of serum uric acid for prognosis prediction of traumatic brain injury by discrimination and calibration.Methods A total of 330 patients with traumatic brain injury (GCS 3~14) admitted to the First Affiliated Hospital of Soochow University between Nov.2010 and Oct.2012 were enrolled.Patients were divided into a survival group (GOS 2~5) and a death group (GOS 1).Logistic regression models were created with serum uric acid, blood glucose and serum uric acid + blood glucose, respectively.Discrimination and calibration were evaluated by ROC curve, calibration curve and Hosmer-Lemeshow test.Results AUCs of serum uric acid, blood glucose and uric acid+blood glucose were 0.7178, 0.7809 and 0.8134, respectively.The p values of Hosmer-Lemeshow test for serum uric acid, blood glucose, serum uric acid + blood glucose were 0.1508, 0.3366 and 0.8179, respectively.Calibration curves of them were close to the line of perfect prediction.Conclusion Hyperuricemia in the early stage is a risk factor for patients of TBI, and it could be used as a novel predictor owing to its good discrimination and calibration for prognosis prediction of TBI.
Keywords：Traumatic brain injury (TBI)Uric acidDiscriminationCalibrationPrognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 714-718 )