Observation of curative effect of reverse thrombolysis combined with PCI on acute ST-segment elevation myocardial infarction
Guo Zi-tong
Shen Xin
Wang Zhao
A Mu-ti
Mu Ye-sai
Lei Jian-xin
Zhou Li-ying
Yu Xiao-lin
Lai Hong-mei
A De-li-jiang
A Si-ka-er
Li Guo-qing
Abstract：Objective To observe the effect of reverse thrombolysis combined with PCI on acute ST-segment elevation myocardial infarction.Methods 48 patients with acute ST-segment elevation myocardial infarction were randomly divided into two groups: reverse thrombolysis combined with PCI group and direct PCI group, including 24 patients respectively.Reverse thrombolysis combined with PCI means that pro-urokinase is injected into the occlusion segment for reverse thrombolysis, then PCI is performed.The incidences of slow-flow and no-reflow, the incidence of reperfusion arrhythmia, the incidence of bleeding in the two methods were compared.Results In the reverse thrombolysis combined with PCI group, slow-reflow in 1 case, transient bradycardia after PCI in 1 case, while in PCI group, slow-reflow in 3 cases, no-reflow in 2 cases, transient ventricular tachycardia after PCI in 6 cases, electrical conversion given to 2 cases, transient bradycardia in 2 cases, no cerebral hemorrhage and gastrointestinal bleeding occurring in both groups, and symptoms of repeated heart failure occurring in 2 cases.After comparison of both groups, the incidence of postoperative slow-reflow and no-reflow (P=0.013), and the incidence of reperfusion arrhythmia (P=0.001) were statistically significant, and the incidence of bleeding (P=1.000) was of no statistical significance.Conclusions With regard to the acute ST-segment elevation myocardial infarction, reverse thrombolysis combined with PCI can significantly reduce the occurrence of slow-reflow and no-reflow and reperfusion arrhythmia, and thus improve the long-term prognosis of patients, without increasing the incidence of bleeding and other complications.
Keywords：Reverse thrombolysisNo-reperfusionReperfusion arrhythmiaST segment elevation myocardial infarction(STEMI)Percutaneous coronary intervention(PCI)
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 454-457 )