The value of changes in transcutaneous partial pressure of oxygen induced by passive leg raising in evaluating fluid responsiveness
Fang Hong-long
Wu Hua-yong
Chen Juan
Luo Jian
Wang Dan-qiong
Zhang Wei-wen
Abstract：Objective To test whether the changes of transcutaneous partial pressure of oxygen (PtcO2)during passive leg raising(PLR)test evaluate fluid responsiveness. Methods Eighty-nine mechanically ventilated patients who need fluid evaluation admitted from January 2014 to December 2015 were prospectively recruited. Hemodynamic parameters monitored by a pulse indicator continuous cardiac output(PiCCO) device and PtcO2, monitored by an transcutaneous oxygen monitoring device were studied at baseline and after PLR. The correlation between PLR-induced CI change(△CI)and PtcO2(△PtcO2)was analyzed by Pearson analysis. The value of△PtcO2 induced by passive leg raising to predict fluid responsiveness was evaluated by receiver operating characteristic(ROC)curves. Fluid responsiveness was defined as an increase in cardiac index(CI)of 15%or greater after PLR(responders:△CI≥15%;nonresponders:△CI<15%). Results A total of 89 patients were enrolled in this study, of whom 52 had a CI increase of≥15%after PLR(responders). After PLR, CI and PtcO2 were both sig-nificantly increased in the response group compared with baseline (P<0.05), while no significant changes were observed in the non-response group(P>0.05). △CI and △PtcO2, after PLR were strongly correlated(r=0.829,P<0.05). After PLR, the area under ROC curve of △PtcO2 was 0.911. An increase of>11.5%in△PtcO2 predicted fluid responsiveness with a sensitivity of 84.7%and speci-ficity of 90.4%. Conclusion The change of PtcO2 induced by PLR is a non-invasive and easy way to predict fluid responsiveness in critical patients.
Keywords：Transcutaneous partial pressure of oxygen(PtcO2)Passive leg raising(PLR)Fluid responsiveness
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 318-321 )