Application value of serum IFABP, creatine kinase, C-reactive protein detection in early diagnosis of strangulated intestinal obstruction
Zhang Li-chun
Zhu Zhe
Wang Yu
Abstract：Objective To investigate the application value of serum intestinal fatty acid binding protein (IFABP),creatine kinase (CK) and C-reactive protein (CRP) detection in early diagnosis of strangulated intestinal obstruction,in order to provide reference for early diagnosis of strangulated intestinal obstruction.Methods The levels of serum IFABP,CK,CRP were detected by the blood of 164 intestinal obstruction patients,86 surgery intestinal obstruction including 38 simple intestinal obstruction patients (simple intestinal obstruction group) and 48 strangulated intestinal obstruction patients (20 necrosis intestinal obstruction group and 28 non-necrosis).These were compared with 78 non-surgery intestinal obstruction patients (control group) and 40 healthy adults (normal control group).The levels of serum IFABP,CK,CRP were compared between surgery intestinal obstruction and non-surgery intestinal obstruction.Results The levels of serum IFABP,CK,CRP were not obviously increased in non-surgery intestinal obstruction group compared with those in the normal control group (P ＞ 0.05),while those of the strangulated intestinal obstruction group were significantly higher than the normal control group (P ＜0.001).The levels of serum IFABP,CK,CRP were higher in the strangulated intestinal obstruction cases without intestinal necrosis than simple intestinal obstruction patients (P ＜ 0.05,P ＜ 0.001,P ＜ 0.001).The levels of serum IFABP,CK,CRP in the necrosis intestinal obstruction group were higher than those in non-necrosis group (P ＜ 0.05,P ＜ 0.001,P ＜ 0.001).There were positive correlations between the three indexes of serum IFABP,CK,CRP in strangulated intestinal obstruction patients (r =0.8211,r =0.8546,r =0.6497,all P ＜ 0.001).Conclusion The detection of levels of IFABP,CK,CRP can not only provide reference for early diagnosis of strangulated intestinal obstruction,but also be used as judgment of degree of intestinal strangulation injury.The combination detection of the three indexes has more clinical application value for early diagnosis of strangulated intestinal obstruction.
Keywords：Intestinal fatty acid binding protein (IFABP)Creatine kinase (CK)C-reactive protein (CRP)Strangulated intestinal obstructionEarly diagnosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 246-249 )