Clinic study of early postoperative application of CRRT in severely electric burned patients

Liu Wei; Xu Zhao-rong; Chen Zhao-hong

doi:10.3969/j.issn.1002-1949.2017.03.007

Abstract：Objective To investigate early postoperative application of continuous renal replacement therapy (CRRT) contributing to severely electric burned patients.Methods The clinical characteristics of forty-three patients with severely electric burn were collected and randomly divided into traditional group and CRRT group,twenty-two patients acquire postoperative CRRT and twenty-two patients in traditional therapy.The inflammatory cytokines IL-1 β,TNF-α and myoglobin in serum of the patients in both groups were detected in preoperative and postoperative (1 h and 72 h after operation)time.Complications and results of two methods were analyzed retrospectively.Results Two groups had no differences in occurrence rate of acute renal failure (x2 =0.616,P =0.4325 ＞ 0.05).IL-1 β,TNF-αnormally increased in both groups and rose a lot more after operation (1 h),while decreased within 72 h after operation.IL-1 β and TNF-α in CRRT group dropped a lot more compared with traditional group (t =15.916,9.522,P＜ 0.05).Myoglobin in both groups came down after burn by degrees,and CRRT group decreased more compared with traditional group (t =9.208,P＜0.05);there were differences in the occurrence of sepsis and MODS (sepsis x2 =6.776,P =0.0209 ＜ 0.05;MODS x2 =6.435,P =0.011 ＜0.05),and no difference in mortality of both groups.Conclusion CRRT can relieve the symptom of inflammatory and risk of MODS by cleaning up inflammatory factors and toxin effectively,yet have no differences in mortality.