Optimization therapy of community- acquired pneumonia supported by pharmacokinetics and pharmacodynamics
Zhang Li-yuan
Zhu Bao-feng
Gu Peng
Abstract：Community-acquired pneumonia(CAP)is one of the most common infectious diseases in the emergency department and a major cause of morbidity and mortality worldwide, which is a serious threat to human health. However, current antibacterial therapy for CAP is unsatisfactory, and the increase in antimicrobial resistance complicates treatment. With the development of pharmacokinetics/pharmacodynamics(PK/PD), application of PK/PD theory in development and optimization of antibacte?rial dosing regimens is of crucial importance in the enhancement of success therapy, reduction of adverse effects, and minimization of resistance emergence. This paper introduced epidemiology of CAP and opti?mization of antibacterial therapy for CAP under PK/PD theory by reviewing the related articles and com?prehensive analysis.
Keywords：Community-acquired pneumonia(CAP)Pharmacokinetics(PK)Pharmaco-dynamics(PD)Antibacterial therapy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 984-987 )