Efficacy and safety of bivalirudin in percutaneous coronary intervention after fibrinolysis for acute myocardial infraction
GU Xiao-long
LIN lin
GONG Zhi-hua
RUAN Yun-jun
XIAO Hua
XIANG Ding-cheng
Abstract：Objective To evaluate the efficacy and safety of Bivalirudin(BIV)in patients with acute ST-segment elevation myocardial infarction(STEMI)undergoing percutaneous coronary interven?tion(PCI)after thrombolysis. Methods A total of 112 patients suffered from acute STEMI received PCI after thrombolytics were randomly divided into 2 groups,of whom 51 patients received BIV during PCI procedure and 61 patients received unfractionated heparin(UFH)during PCI procedure. The throm?bolysis in myocardial infarction (TIMI) flow grade before and after PCI was assessed between two groups. The incidence of the major adverse cardiac and cerebrovascular events(MACCE)and bleeding during hospitalization were compared between the two groups. Results There were no differences in TIMI flow grade before and after PCI. The major bleeding rate in BIV group during hospitalization was similar with the patients treated with UFH,while the incidence of MACCE was lower in the BIV group (3.9% vs. 16.4%,P=0.03). Conclusion Bivalirudin and heparin had the same bleeding rate intreating the STEMI patients after thrombolytic therapy who subsequently underwent PCI,while bivaliru?din was associated with less MACCE compared with UFH.
Keywords：BivalirudinHeparinThrombolytic therapyPercutaneous coronary intervention(PCI)ST-segment elevation myocardial infarction(STEMI)
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 595-599 )