Follow-up of the lung function in long-term survival patients with acute paraquat poisoning

YAO Dong-qi; LI Min; HAO Shu-ting; GAO Heng-bo; GENG Zuo-jun; WANG Xia; SU Jian-ling; GONG Yu; MENG Zhao-hua; WANG Rong-ying; TIAN Ying-ping

doi:10.3969/j.issn.1002-1949.2016.06.009

Abstract：Objective To further study the prognosis of lung injury induced by paraquat ( PQ) through the follow-up of the lung function 6 months after poisoning in long-term survival patients with acute PQ poisoning. Methods Fifty cases of PQ poisoning patients were retrospectively reviewed in our department from September 2010 to July 2012, and were divided into the mild group and the severe group according to the clinical manifestations and lung CT. TLC%, RV%, RV/TLC% and TLcoSB% were determined 6 months after PQ poisoning. The difference of lung function in the two groups was known by statistical analysis with SPSS 20. 0. Results TLC%, RV%, RV/TLC% and TLcoSB% was 94. 86 ± 10. 88, 95. 14 ± 32. 32, 25. 24 ± 7. 71 and 95. 48 ± 12. 26, respectively in mild group. TLC%, RV%, RV/TLC% and TLcoSB% was 97. 69 ± 11. 15, 98. 52 ± 24. 56, 27. 37 ± 4. 44 and 83. 48 ± 11. 21, respectively in severe group. The abnormality rate of restrictive or obstructive ventilatory disorder or diffusion disorder in mild group showed no significant difference with that in severe group(P>0. 05). The abnormality rate of indices of the lung function in mild group showed no significant difference with that in severe group (P>0. 05). TLcoSB% in mild group showed statistically difference with that in severe group(P<0. 05). The other indices in mild group showed no significant difference with that in severe group(P>0. 05). Conclusion PQ poisoning can decrease certain extent diffusion capacity in survival patients at 6 months. The alveolar damage in severe group is more serious than that in mild group. However, this difference could not make the abnormal rate of diffusion disorder in two groups show any statistical difference.