Regional citrate anticoagulation in criticalpatients with liver dysfunction
WANG Wei
CHANG Ping
LIU Zhan-guo
PENG Sheng
LI Xia-xi
ZHAO Ming
CEN Zhong-ran
Abstract：Objective To explore the safety of regional citrate anticoagulation forcontinuous veno - venous hemofiltration (CVVH) in critical patients with liver dysfunction. Methods 77 patients underwent continuous renal replacement therapy ( CRRT ) using citrate as anticoagulation were retrospectively included in this study. The patients were divided into group A (normal liver function), group B (liver dysfunction MELD≤25. 13) and group C (liver dysfunction MELD > 25. 13). Respective values of blood gas (pH, base excess), lactic acid, ionized calcium and total calcium in 2 hours prior to CRRT and 6 hours after CRRT were observed and analyzed. Results A total of 77 patients (103 cases of CRRTs) were included in the study. Comparing to 2 hours prior to CRRT, the ionized calcium, total calcium and base excess in 6 hours after CRRT were significantly higher in all groups(P < 0. 05), pH and lactic acid in 6 hours after CRRT were similar in all groups( P > 0. 05). Ionized calcium, total calcium, base excess were not significantly different in 3 groups in 6 hours after CRRT( P > 0. 05). Conclusions Regional citrateanticoagulation in CVVH does not cause acid - base balance and electrolyte disorder. Thus it is safe to operate in liver dysfunction patients.
Keywords：Continuous renal replacement therapy(CRRT)CitrateLiver functionAnticoagulationContinuous veno - venous hemofiltration(CVVH)
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 52-55 )