Protective effects of penehyclidine hydrochloride and anisodamine against the organ injuries in rabbits with traumatic shock
LIANG Peng-chong
CAO Yi-zhan
WANG Yu-qing
ZHANG Qiong
SHI Ya-jun
FAN Dong-mei
WANG Da-jun
WANG Hou-qing
ZHAO Ning-jun
YAN Xian-liang
XU Tie
Abstract：Objective To investigate the protective effects of penehyclidine hydrochloride on organ injury in rabbits with traumatic shock. Methods The animal model of traumatic shock was established by Lamson's method.Twenty-four rabbits were randomly divided into control group ( Con group ) , traumatic shock with normal saline group ( NS group ) , traumatic shock treated with penehyclidine hydrochloride group(PHC group)and anisodamine(ANI group).At pre-shock, tele-shock, four timepoints after resuscitation, mean arterial pressure ( MAP ) and heart rate ( HR ) were monitored.Arterial blood lactate ( ABL) concentration was measured by spectrophotometry.By the end of the experiment, the pathological changes of tissue samples of the liver, lung and intestine were observed under microscope.Results There were no significant differences of MAP at pre-shock among the four groups.At tele -shock, the MAP of all rabbits in NS group, PHC group and ANI group significantly decreased.At eachtime point after resuscitation, the MAP in PHC group and ANI group significantly rose again, but the MAP in NS group did not recover to the level of pre-shock and was significantly lower than that in Con group, PHC group and ANI group.There was no significant group difference in HR at pre-shock and tele-shock.At eachtime point after resuscitation, the HR of rabbits in NS group was significantly decreased.The HR of rabbits in PHC group was slightly decreased, higher than that in NS group but lower than that in ANI group.There were no significant group differences in plasma ABL concentration at pre-shock time point.Compared with pre-shock and control group, the plasma ABL concentration in NS group, PHC group and ANI groupwas significantly increased;at tele-shock and each time point after resuscitation.The plasma ABL concentration was significantly higher in NS group than that in PHC and ANI group.The results of pathology showed that tissue injury of rabbits in PHC and ANI groups was significantly reduced compared with NS group.Conclusion PHC and ANI can stabilize hemodynamics in rabbits with traumatic shock.There is a protective effect on organ injury induced by traumatic shock.
Keywords：Traumatic shockPenehyclidine hydrochloride( PHC)Arterical lactic acid ( ABL)Mean arterial blood pressure( MAP)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1130-1133,1134 )