The changes and clinical significance of serum markers in myocardial infarction patients after reperfusion
FAN Yan-hui
DAI Rui
PU Yu
Abstract：Objective To evaluation of the myoglobin/carbonic anhydraseⅢ(Mb/CAⅢ) ratio and MB isoenzyme of creatine kinase ( CK-MB) as a noninvasive marker in detecting coronary artery reperfusion after thrombolysis. Methods The study consisted of 107 cases of acute myocardial infarction.54 patients received thrombolytic therapy( interventional therapy group, n=54) , 53 patients undergoing coronary angioplasty(thrombolytic therapy group, n=53).The Mb/CA III ratio and CK-MB were measured in the course of treatment.Results Thrombolytic therapy was followed by a (9.1 ± 2.2)fold increase in myoglobin and (10.8 ±3.3)fold increase in CK-MB fraction during the first hour of treatment, while CAⅢremained unchanged.The peak value of Mb/CAⅢratio was found at 2 h and that of CK-MB fraction at 8 h after thrombolysis.The reperfusion time point during primary angioplasty and follow-up of cardiac markers revealed that cut-off points of 3 and 10 h for the peak values of Mb/CAⅢratio and CK-MB fraction can be used as indicators for reperfusion, respectively.Mb/CAⅢratio measured before treatment and 2 and 4 h after the onset of treatment screened 41 of those 45 patients with probable reperfusion after thrombolysis.Conclusion The serum Mb/CAⅢratio can be used to evaluate the rate of infarction reperfusion success in patients with acute myocardial, and to screen the needs for percutaneous transluminal coronary angioplasty.
Keywords：Acute myocardial infarction( AMI)Myoglobin( Mb)Carbonic anhydraseⅢ( CAⅢ)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1112-1117 )