Effects of intravenous rhBNP after primary PCI on left ventricular function in patients with anterior wall acute myocardial infarction
SUN Jing
LIU Jun-xiang
YANG Guo-hong
ZHOU Xin
ZHAO Ji-hong
JIANG Tie-min
LI Yu-ming
Abstract：Objective To investigate the effects of intravenous recombinant human brain natriuretic peptide (rhBNP) after primary percutaneous coronary intervention (PCI) on neuroendocrine hormone level, inflammatory factor level and left ventricular function in patients with anterior wall acute myocardial infarction ( AMI ) . Methods Eighty consecutive patients with anterior wall AMI after primary PCI were randomly divided into therapy group (n=40) and control group (n=40).Patients in therapy group were treated with intravenous rhBNP (1.5 μg/kg) followed by continuous infusion [0.01μg/(kg? min)]for 72 h and then 0.5 mg/d for 3 days while the control group received conventional treatment.The neuroendocrine hormone level, inflammatory factor level and ventricular function were measured on admission and 7 days later.The major adverse cardiac events ( MACE) were observed during in hospital.Results No significant differences of neuroendocrine hormone level, inflammatory factor level and ventricular function were found between the two groups on admission (P>0.05).The levels of NE, ET-1, PRA, AngⅡand ALD in therapy group were markedly decreased compared with control group after rhBNP treatment (P<0.05), while no apparently differences of ADH were found between the two groups ( P >0.05 ) .The levels of IL -6, hsCRP, sICAM -1 and sVCAM -1 in therapy group were also significantly decreased compared with control group after rhBNP treatment ( P<0.05).After rhBNP treatment the LVEF was significantly increased and LVEDD was significantly decreased compared with control group (P<0.05) ,while no markedly differences of LAD were found (P>0.05).No adverse events during drug infusion were observed and MACE during in hospital was also similar in both groups.Conclusion Patients with anterior wall AMI after primary PCI treated with rhBNP can markedly inhibit left ventricular remodeling and improve left ventricular function which may be related with modulatory effects of rhBNP on neuroendocrine hormone and local inflammatory state.
Keywords：Key words] Recombinant human brain natriuretic peptide( rhBNP)Percutaneous coronary intervention ( PCI)Anterior wall acute myocardial infarctionLeft ventricular function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1107-1111 )