The damage of pulmonary microvascular endothelial cell barrier and acute respiratory distress syndrome
HAN Feng
Abstract：The acute respiratory distress syndrome ( ARDS) is a major cause of acute respiratory failure characterized by a diffused alveolar damage , formation of hyaline membranes , protein -rich edema fluid in the alveolar spaces , capillary injury and disruption of the alveolar epithelium , and the most prominent clinical manifestation of ARDS is refractory hypoxemia . Despite improvements in intensive care with optimal ventilation support and fluid balance , its development also leads to high mortality, as well as short -and long -term complications.Therefore, early recognition of this syndrome and application of demonstrated therapeutic interventions are essential to change the natural course of this devastating entity .In this review article , we describe the mutual relation between the damage of pulmonary microvascular endothelial cell ( PMVECs ) barrier and the occurrence and development of ARDS .Specifically , we describe the Berlin definition of ARDS and barrier function of PMVECs, as well as the permeability changes , the abnormal apoptosis and secretion and the dysfunction of PMVECs in the development of ARDS in order to further discuss its possible pathophysiological mechanism.
Keywords：Pulmonary microvascular endothelial cells (PMVECs)Endothelial barrierAcute lung injury ( ALI)Acute respiratory distress syndrome ( ARDS)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1048-1053 )