The protective role and mechanism of edaravone combined with hemoperfusion technology in multiple organ injuries caused by paraquat poisoning

doi:10.3969/j.issn.1002-1949.2015.11.011

Abstract：Objective To discuss the prevention and treatment effect of edaravone combined with hemoperfusion technology on multiple organ injuries caused by paraquat poisoning .Methods By means of prospective study , 60 cases of paraquat poisoning patients were randomly divided into edaravone combined with hemoperfusion in the treatment group (group A with 30 cases) and the control group ( group B with 30 cases ) .We detected respectively oxygen saturation ( SaO2 ) , renal function , liver function and myocardial enzyme indexes on the 1 d, 7 d, 3 d, 14 d, as while as detected malondialdehyde ( MDA ) , superoxide dismutase ( SOD ) , and the content tumor necrosis factor -α( TNF-α) and interleukin -10 ( IL-10 ) in serum by ELISA .Results ①The mortality of the two groups were compared, the treatment group was lower than the control group (P<0.05).②The level of ALT, AST, CK-MB, Cr of both groups have different degrees of change , furthermore the data in group A on 7 d, 3 d were significantly better than those in group B (P<0.05).③The plasma MDA levels were elevated in both groups , and reached the peak on 3 d;SOD levels decreased significantly on 1 d, and then increased gradually , on 14 d, the level of SOD in treatment group recovered to normal , but it was still lower in the control group than normal level (P<0.05);compared with group B, the content of MDA in plasma was lower in group A, and the activity of SOD (P<0.05) was higher than group B.④The levels of serum TNF-αand IL-10 were significantly increased in these two groups , especiallyin group B, and reached the peak on 3 d.Conclusion Edaravone has a good protective effect on the paraquat poisoning by scavenging free radicals and regulation of inflammatory responses , so as to achieve the protective effect of organs , and further reduce the mortality .