Prognostic value of peripheral absolute lymphocyte count in the patients of sepsis
Abstract：Objective To investigate the peripheral total lymphocyte count ( lym) to predict the value of the prognosis of patients with sepsis .Methods 116 patients with sepsis were collected in our hospital ICU from January 2013 to January 2014 through a prospective study .Blood samples for lym were taken on the 1st, 3rd, 7th day of hospitalization;according to 28-day and 90-day mortality they were divided into the survival group and death group; the lymphocyte count , the APACHEⅡ score, comorbidities between each group were compared .Results ①There was no significant difference between the lym on the 1st day of hospitalization in survival group and non -survival group, but ALB concentrations and lym on the 3rd, 7th day of hospitalization were statistically significant higher in the survival group compared with non -survival group.The age, serum creatinine, APACHEⅡ score and the proportion of patients who associated with renal failure and heart failure in non -survival group were significant higher than the survival group .②The lymphocyte count had a statistically significant for predicting the 28-day and 90 -day mortality, ROC curve showed that the maximum area under the ROC curve ( AUC ) of lym about prognosis for predicting the 28 -day and 90 -day mortality was (0.772, 0.785) on the 7th day, the cut-off point value (cut-off) was 1.0 ×109/L.③According to the lymphocyte count on the 7th day was whether or not higher than 1.0 ×109/L, divided into two groups (lymphocytic <1.0 ×109/L and lymphocyte >1.0 ×10 9/L group), the age, serum creatinine, APACHEⅡ score, 28 -day and 90 -day mortality in lymphocytic <1.0 ×109/L group were significantly higher than that of lymphocyte >1.0 ×109/L group.④In multivariate analyses, lymphopenia (defined as an absolute lymphocyte count <1.0 ×109/L on the 7th day) with tumor and mechanical ventilation were found to be independently factors associated with 28-day survival and 1-year survival ( P <0.05 ) .Conclusion Lymphopenia ( defined as an absolute lymphocyte count <1.0 ×109/L on the seventh day ) is an independent predictor for predicting the prognosis of patients with sepsis, if combined with tumor and mechanical ventilation , it can better predict the survival .
Keywords：Peripheral absolute lymphocyte countSepsisPrognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 977-981 )