Analysis of therapeutic effect of lipid emulsion for myocardial infarction in acute severe organophosphorus pesticide poisoning

SANG Zhen-zhen; GUO Jin-ping; Li Yong

doi:10.3969/j.issn.1002-1949.2015.10.012

Abstract：Objective To explore the therapeutic effect of lipid emulsion for myocardial infarction in acute severe organophosphorus pesticide poisoning .Methods One hundred and thirty-six cases with myocardial infarction in acute severe organophosphorus pesticide poisoning were randomly divided into control group and treatment group .The control group contains 65 patients , which were given routine treatment, for example gastric lavage, cathartic, antidote, hemoperfusion.The treatment group contains 71 patients, received lipid emulsion by intravenous instillation on the basis of routine treatment . The death rate , the duration of EICU stays , and myocardial infarction indexes which contains creatine kinase ( CK ) , creatine kinase isoenzyme ( CK -MB ) , lactate dehydrogenase ( LDH ) , aspertate aminotransferase (AST), acetyl cholinesterase (ChE), were compared between two groups .Results The acetyl cholinesterase activity level in treatment group was much higher than that in control group with significant difference (P<0.05) after organophosphorus pesticide poisoning , at 3, 5, 7 d which were the observation points .The myocardial infarction indexes , CK, CK-MB, LDH, and AST in treatment group were superior to control group (P<0.01) after lipid emulsion treatment.In the treatment group, the death rate was decreased largrly , and the duration of EICU stays were shorter compared with the control group ( P <0.05 ).Conclusion The lipid emulsion can reduce the degree of elevated myocardial enzymes , accelerate the resume of the activity of ChE in blood , and relieve the myocardial infarction induced by acute severe organophosphorus pesticide poisoning , decrease the death rate and shorten the duration of EICU stays .