Study on the effect of serum NT -proBNP levels in hyperbaric oxygen therapy on severe traumatic brain injury patients and correlation with prognosis
Abstract：Objective To explore effects of serum NT -proBNP levels in hyperbaric oxygen ( HBO) therapy on severe traumatic brain injury patients and correlation with prognosis .Methods One hundred severe traumatic brain injury patients were randomly divided into the control group (50 cases) and the therapy group (HBO therapy group, 50 cases).The control group received craniotomy operation and conventional drug treatment , and the therapy group was given HBO therapy in addition to the same treatment received by the control group .Serum NT-proBNP levels on day 4, 7, 10, 14 and 21 after operation were determined , and the scores of Glasgow coma scale ( GCS) were measured among the two groups.Glasgow outcome scale (GOS) was evaluated in follow -ups 3 months after injury.Results Serum NT -proBNP levels of the severe traumatic brain injury patients of both groups showed no statistical difference before treatment (P>0.05).After HBO treatment, serum NT-proBNP level was decreased significantly (P<0.05), and GCS also was increased significantly in the therapy group (P<0.05).GOS made 3 months after injury indicated that the number of patients with better prognosis in the HBO group increased obviously, when a co MParison was made with the control group (P<0.05). Conclusion HBO therapy can rapidly reduce serum NT -proBNP level in patients with severe craniocerebral injury , improve the prognosis of patients , improve the clinical efficacy .
Keywords：Severe traumatic brain injuryNT-proBNPHyperbaric oxygen ( HBO)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 900-902,903 )