Study of dexmedetomidine combined with dezocine in sedation and analgesia on patients with multiple traumas

doi:10.3969/j.issn.1002-1949.2015.10.007

Abstract：Objective To evaluate the efficacy and safety of dexmedetomidine combined with dezocine in sedation and analgesia in the patients with multiple traumas .Methods Sixty patients with multiple traumas were enrolled and randomly divided into dexmedetomidine combined with dezocine group (A group and midazolam combined with fentanyl group (B group) with thirty cases in each group. These indicators as the incidence rate of severe agitation and delirium , the cost of sedation and analgesia drug, the total cost in ICU (except for operation expenses ), the duration of mechanical ventilation , the ICU stay, the incidence rates of cardiovascular adverse events and respiratory depression events were compared between two groups .Results The incidence rates of severe agitation and delirium in group A were significantly less than group B .The incidence rates of cardiovascular adverse events and respiratory depression events in group A were significantly less than group B .The duration of mechanical ventilation and the ICU stay in Group A were shorter than group B (P<0.05).Although the cost of sedation and analgesia drug in group A was higher than that in group B (P<0.05), the total cost in ICU (except for operation expenses ) showed no significant difference ( P >0.05 ).Conclusion Dexmedetomidine combined with dezocine is effective and safe for sedation and analgesia in patients with multiple traumas , which could reduce the occurrence of severe agitation and delirium , shorten the duration of mechanical ventilation and the ICU stay , and decrease the incidence rates of cardiovascular adverse events and respiratory depression events .