Characteristics of the dynamic changes of coagulation function in patients with severe burn and its relationship with prognosis

doi:10.3969/j.issn.1002-1949.2015.10.006

Abstract：Objective The aim of present study was to find out the characteristics of coagulation function , and to investigate the relationship between the coagulation dysfunction and the prognosis in the critically burned patients .Methods The retrospective observation study was employed .According to the outcome of 90-day-mortality, 15 severe burn patients were divided into 2 groups, survival and non-survival groups . The number of platelet and the parameters of coagulation function were dynamically observed during 28 days following heat injury . Results In the first two days after admission, the parameters of coagulation , prothrombin time ( PT) and activated partial thromboplastin time ( APTT) , were significantly prolonged in both groups , and also these two parameters in non -survival group were longer than those of survival group (P<0.05).The Antithrombin Ⅲ (AT-Ⅲ) were already in the deficiency state in both groups on admission .The level of AT -Ⅲ in the survival group recovered gradually during the first week , but in the non-survival group , the deficiency state of AT-Ⅲ was persistent till the end of observation period .Although the level of platelet number was dramatically elevated on admission , the state of thrombocytopenia in both groups was persistent for the subsequent week .Conclusion The coagulation dysfunction exists at early phase of severely burned patients, and mainly appears as the state of coaguplopathy , along with thrombocytopenia; and the sustained state of AT-Ⅲdeficiency is characterized by the poor outcome of severely burned patients .