The predictive value of the urinary KIM-1 and cystatin C in early diagnosis of acute kidney injury occurred in patients with severe pneumonia
GAO Fei
YAN Jie
Abstract：Objective To investigate the predictive value of the urinary kidney injury molecule-1 ( KIM-1) and cystatin C in early diagnosis of acute kidney injury occurred in patients with severe pneumonia .Methods We prospectively collected 70 cases of severe pneumonia patients who admitted to ICU and EICU in our hospital from Oct .2013 to Oct.2014.0, 3, 6, 12, 24, 48 h urine and blood samples were collected , using enzyme -linked immunosorbent assay ( ELISA ) to detect KIM-1 and the latex particle enhanced immunoturbidimetric method transmittance ( PETIA) to detect cystatin C.Results During this period the ICU and EICU hospitalization AKI were 32 cases, AKI incidence was 45.71%.AKI urinary KIM-1 at 6, 12, 24, 48 h and cystatin C in 12, 24, 48 h was higher than non -AKI group (P<0.05);6 h and 12 h urinary KIM-1 cystatin C and diagnosed AKI 24 h when serum creatinine (sCr) were positively correlated (r=0.883, P=0.000; r=0.703, P=0.000).Area under the ROC curve for 6 h urinary KIM -1 and 12 h cystatin C (AUC) were 0.875 (95%CI 0.795 ~0.955) and 0.836 (95%CI 0.743 ~0.929), respectively.Conclusion The urinary KIM-1 and cystatin C appear earlier than the sCr , so the detection of urinary KIM -1 and cystatin C has a certain value for patients with severe pneumonia to predict the occurrence of acute kidney injury .
Keywords：Kidney injury molecule -1 (KIM-1)Cystatin CSevere pneumoniaAcute kidney injury (AKI)
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 840-843 )