The application of mild hypothermia blood purification in postoperative cardiac shock of valvular heart disease

doi:10.3969/j.issn.1002-1949.2015.09.015

Abstract：Objective The mild hypothermia therapy had been used in blood purification , and to observe its protective effects on postoperative cardiac shock in valvular heart disease .Methods Ninety-five patients were randomly divided into the normothermic blood purification group ( NT group, n=47) and mild hypothermia blood purification group (HT group, n=48).Cardiac index (CI), the ratio of oxygen delivery ( DO2 ) and oxygen consumption ( VO2 ) , score of the APACHEⅢ and multiple organ dysfunction syndrome (MODS), ICU stays, mechanical ventilation time, CBP time, incidence of infection, arrhythmia, blood loss and mortality within two groups at the 0, 1, 2, and 3 days were recorded and compared .Results There was no significant difference when compared within two groups at the day 0 (P>0.05).Compared with the day 0, those clinic monitoring data of CI, DO2/VO2 ratio, score of the APACHEⅢand MODS in NT group had no significant difference at each days ( P>0.05);DO2/VO2 ratio had been improved significantly in HT group at the day 1 (P<0.05), the other indexs had no significant difference ( P >0.05 ); at the day 3, all clinic monitoring data had significant differences (P<0.05).ICU stays, mechanical ventilation time, CBP time and the mortality in HT group were less than those in NT group (P<0.05), but the cases of infection, arrhythmia and blood loss between two groups had no significant difference ( P>0.05).Conclusion Hypothermia blood purification can safely and effectively improve the early imbalance of oxygen supply , postpone the progress of disease and improve the prognosis for postoperative cardiac shock patients with valvular heart disease.