Clinical effects of immune -enhanced enteral nutrition supplemented with arginine and ω-3 polyunsaturate fatty acid in patients with septic shock
WEI Guang-ying
LU Rong-heng
TAN Yi-jiang
Abstract：Obej ctive To investigate the effect of immune -enhanced enteral nutrition supplemented with arginine and ω-3polyunsaturated fatty acid on the host immune and inflammatory responses in patients with septic shock .Methods Sixty-seven patients with septic shock from January 2011 to December 2014 were divided into two groups:intervention group and control group .Intervention group included 21 males and 15 females with an average age of 62.53 ±13.29 (range, 21 to 80), and control group included 17 males and 14 females with an average age of 59.13 ±14.43 ( range, 38 to 78).Intervention group was given enriched arginine and ω-3 polyunsaturated fatty acid enteral nutrition: Impact, while the control group was only given isocaloric standard enteral diet: Milupa GmbH.Enteral nutrition was started within 24 hours after admission via naso -jejunum tube and continued for 14 days.The inflammatory responses ( CRP and PCT ) , immune index including the continue change of percentage of lymphocyte , CD4, CD8, CD4/CD8, HLA -DR and the levels of serum protein before and on the 7 th and 14 th day after therapy were measured .The APACHEⅡscores were evaluated on the first day and 14 days after therapy .Results There were no significant differences of age, gender, primary disease and the scores of APACHEⅡ between two groups before received therapy.①On the 7th and 14th day after the treatment, the inflammatory responses were decreased insignificantly in both groups , and the intervention group decreased more apparently .②With the development of treatment , the percentage of lymphocyte CD 4, CD8, CD4/CD8 and HLA -DR were increased in both groups .The immune index of intervention group improved more apparently .③There were significant difference between two groups in improving nutritional status .④Compared to pre -therapy, the APACHEⅡscores of two groups , which were evaluated on the 7th day after therapy, were decreased , while the therapy group decreased significantly .Conclusion Immune -enhanced enteral nutrition supplemented with arginine and ω-3 polyunsaturated fatty acid would control inflammatory response and improve the immune function of patients with septic shock .
Keywords：Arginineω-3 polyunsaturated fatty acidEnteral nutritionSeptic shock
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 802-807 )