The significance of thoracic fluid content and PaO2/FiO2 in the management of fluid infusion for septic ARDS patients
Abstract：Objective To observe the changes of thoracic fluid content ( TFC) and PaO2/FiO2 in septic acute respiratory distress syndrome (ARDS) patients, and to explore the effects of TFC on the management of fluid infusion , a perspective control study is performed .Methods A total of 58 severe septic acute lung injury patients were chosen in the Emergency and ICU department in Shanghai Changzhen Hospital and in Shanghai People's Hospital of Putuo District from Jan .2012 to Jun.2014 . TEB was utilized for measuring the TFC , and oxygenation index was detected .Correlation of TFC and PaO2/FiO2 were analyzed respectively .Simple correlation and simple linear regression were used for statistical analysis .Results Significant negative correlation was found of TFC and PaO 2/FiO2 ( r =-0.67, P<0.01).No correlation was found between TFC and PaO 2/FiO2 in the subgroup with mild ARDS ( r =0.13, P =0.241 ), but in the subgroup with moderate ARDS , significant negative correlation was found (r=-0.49, P=0.013).In the subgroup with severe ARDS, significant negative correlation was found (r=-0.88, P=0.004).These results suggest that for mild or severe ARDS patients , reducing TFC helps to improve oxygenation , but for mild ARDS caused by the increase of blood capilary permeability of the lung disease , the dorp of PaO 2/FiO2 , cannot be improved by reducing TFC . Conclusion TFC has a important role in the fluid management for patients of severe septic ARDS .
Keywords：SepsisThoracic fluid content(TFC)PaO2/FiO2Septic acute respiratory distress syndrome (Septic ARDS)Management of fluid infusion
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 794-797 )