A promoter polymorphism in the ABCG1 gene is associated with coronary artery disease severity in Southern Han Chinese
Abstract：Objective To investigate the association of rs 1378577 A/C single nucleotide polymorphism in promoter region of ABCG 1 and angiographically proven coronary artery disease ( CAD) in Southern Han Chinese .Methods Totally 482 CAD patients and 513 controls were recruited in this study.A case-control study was conducted .rs1378577A/C genotypes were assessed with SNP stream technique.Results No significant difference was found in the distribution of alleles and genotype frequencies in cases and controls ( P>0.05 ) .After adjustment for the conventional risk factors for CAD, no significant associationwas observed between rs 1378577 A/C single nucleotide polymorphism and CAD ( P >0.05 ).The present study showed a significant association betweenvariant ABCG 1 rs1378577 A/C and the number of significantly diseased vessels on CAD in arecessive genetic model after adjustment for the conventional risk factors for CAD (OR 0.724, 95%CI 0.526~0.995, P=0.047). Conclusion rs1378577 A/C single nucleotide polymorphismin promoter region of ABCG 1 is associated to coronary artery disease severity in Southern Han Chinese .
Keywords：Coronary artery diseaseATP binding cassette transporter G1Single nucleotide polymorphism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 619-622,623 )