Relationship of BNP and clinical CPR prognosis analyzed by serum BNP level and its dynamic changes during the early stage of CPR
Abstract：Objective To explore the relationship between the level of B -type natriuretic peptide ( BNP ) in peripheral blood and the recent clinical prognosis of cardiopulmonary resuscitation ( CPR) .Methods A total of 60 victims with sudden cardiac arrest who received CPR were divided into three groups .The victims whose BNP levels are less than 200 pg/mL went into group A .Those whose BNP levels at the time of 12~24 h after CPR are higher than the time of 0 h and 3 h after CPR went into group B, and those whose BNP levels at the time of 12~24 h after CPR are lower than the time of 0 h and 3 h after CPR went into group C .Left ventricular function ( LVEF) was detected 3 h after CPR. These 60 cases were followed -up with ACS 6 months of mortality incidence .Results Spearman rank correlation analysis showed that the serum BNP level 3 h after CPR was negatively correlated with LVEF , 6 months of survival rates of the higher level serum BNP group 3 h after CPR were less than the BNP low expression group .6 months of mortality incidence of group B was obviously higher than that of group A and group C; 6 months of mortality incidence of group C was slightly higher than that of group A . Conclusion The expression of BNP activation at the initial and developing stage may indicate heart failure in those with CPR .At the early stage of CPR , BNP has protective effects on the human body , but the massive expression of BNP activation is associated with serious heart failure , which induced a high mortality of victims with CPR .
Keywords：Cardiopulmonary resuscitation ( CPR)B type natriuretic peptide ( BNP)Heart failureRecent clinical prognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 608-611 )