The significance of plasma estradiol in chronic heart failure of elderly male patients with hypertenstion
Abstract：Objective To observe the variation and clinical significance of plasma estradiol ( E2 ) in chronic heart failure ( CHF) of elderly male patients with hypertenstion.Methods This study included 124 elderly men with CHF, New York Heart Association ( NYHA) class: Ⅱ~Ⅳ, grouped according to the admission blood pressure: 77 patients with hypertension and 47 patients with normotension.Plasma E2 , testosterone ( T ) , and N terminal of B type natriuretic peptide ( NT -proBNP) levels were detected before and after treatment.At the same time, 6 -min walking test (6MWT) and NYHA classification were also performed for these patients.Results ①After treatment, heart failure degree of the two groups were significantly improved, walking distance in 6MWT was longer (P<0.05), and NT-proBNP level was decreased (P<0.05).②After CHF was corrected, E2 level was decreased significantly (P<0.05); but T level was not obviously changed (P>0.05); before treatment, E2 level and the CHF degree were synchronously changed.③Before treatment, the plasma E2 level in CHF patients with hypertension was higher than normotensive patients ( P <0.05 ); after treatment, E2 was decreased significantly (P<0.05).Conclusion Endogenous E2 level is related to the degree of CHF in elderly men.Plasma E2 level is significantly higher in CHF patients with hypertension.These results suggest that E2 has a protective effect on the elderly men of CHF with hypertension.
Keywords：Estradiol( E2 )Heart failure( CHF)HypertensionElderly men
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 522-525 )