Effect of sex hormones on the prognosis of pregnant women with early sepsis

QI Wei-zhen; XU Li-li

doi:10.3969/j.issn.1002-1949.2015.06.003

Abstract：Objective To investigate whether the estradiol, testosterone levels affect the prognosis of pregnant patients with early sepsis. Methods Thirty -nine pregnant patients who accompanied with sepsis from Dec 2012 to Dec 2014 in obstetric ICU of our hospital were selected in this study.According to patients with 28 d survival situation, 10 cases were included into survival group and 29 cases were included into death group.The data between the two groups were analyzed, including the level of estradiol and testosterone, age, body mass index ( BMI ) and APACHEⅡ scores, clinical indexes such as SOFA score, evaluation of each index forecast the prognosis of patients with valid values.Results Serum estradiol level in the survival group was higher than that in the death group, but serum testosterone level, APACHEⅡscore, SOFA scores were lower in the survival group than those in the death group, the difference was statistically significant (P <0.05).There were no significant statistical difference in age, BMI of the patients(P>0.05).ROC curve by Logistic regression analysis has shown that the serum testosterone level, APACHEⅡ scores, SOFA score were independent risk factors for the prognosis of pregnant patients with early sepsis, and they can well predict the prognosis. The critical point for serum testosterone level was 0.64 pmol/L with a sensitivity of 86% and a specificity of 84% which was highest among the above mentioned risk factors.Conclusion Sex hormone levels in pregnant patients with early sepsis have remarkable effect on the prognosis.And we recommend the serum testosterone level to be a clinical indicator for predicting the prognosis of pregnant patients with early sepsis.