Correlation between adverse cardiovascular events and neutrophil and lymphocyte ratio in aged patients with acute heart failure

YAO Guang-hui

doi:10.3969/j.issn.1002-1949.2015.05.013

Abstract：Objective To investigate the correlation between adverse cardiovascular events and neutrophil and lymphocyte ratio (NLR) in aged patients with acute heart failure (AHF).Methods Seventy-eight cases of aged patients with AHF in our hospital from March 2011 to September 2014 were selected as the research subjects, all cases were divided into adverse event group ( n=31 cases) and non-event group ( n =47 ) according to adverse cardiovascular events; general clinical data on admission, routine blood [ white blood cell count ( WBC ) , the number of neutrophils ( NEU ) and lymphocyte count ( LYM) and calculate the ratio between ( NLR) , high-sensitivity c-reactive protein ( hs-CRP) and cardiac function related indicators were compared among two groups;and the receiver-operating characteristic curve ( ROC curve) was drawn to analyze the clinical value of NLR predict the adverse cardiovascular events.Results Compared with the non -event group, heart rate in adverse events group was rapid, WBC counts, NEU, NLR, NT-proBNP, hs-CRP were higher (P<0.05), while LYM, LVEF were lower ( P <0.05 ); Pearson correlation analysis showed that NLR were positively correlated with WBC, NT -proBNP and hs -CRP ( P <0.05 ), while was negatively correlated with LVEF (P<0.05); Multiariable Logistic regression analysis showed that high level of NLR was independently correlated with cardiovascular adverse events in elderly patients with AHF ( P<0.05);ROC curve analysis showed that:the NLR prediction for older patients with AHF area under the curve of cardiovascular adverse events (ROCAUC) was 0.795 (95%CI=0.536~0.927, P<0.05), the best diagnostic cut-off value was 7.49, the sensitivity and specificity were 77.1% and 82.0%respectively;cut-off value of NLR with 7.49 for boundary divided the patients into two groups (NLR acuity 7.49 group and NLR<7.49), NLR acuity 7.49 higher incidence of adverse cardiovascular events in patients with NLR <7.49 group ( P <0.05 ).Conclusion NLR is closely related to the inflammatory reaction and a decreased cardiac function.It is a risk factor for cardiovascular adverse events in elderly patients with AHF, therefore early detecting of NLR has certain clinical significance in judging the prognosis of elderly patients with AHF.